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Advanced Neurovascular Imaging and Research

Advanced Neurovascular Imaging and Research Studies

Current and ongoing research projects at the Cerebrovascular Surgery and Interventions Center

Imaging Studies

Diagnostic imaging tests are crucial in identifying most cerebrovascular problems. These tests enable neurosurgeons to visualize the arteries, vessels, and brain tissue, facilitating safe and accurate diagnoses. However, advancements in technology have resulted in a multitude of cerebrovascular imaging techniques, making it necessary to select the most suitable exam for each clinical scenario to achieve optimal diagnosis and characterization of cerebrovascular disease.

Testing of New or Modified Cerebrovascular Magnetic Resonance Imaging Techniques

Overview
The objective of this study is to evaluate and optimize modifications to existing magnetic resonance imaging (MRI) techniques, and to study whether they could be useful in understanding the blood flow to the brain in normal and abnormal vessels for children and fetuses. Participants will be asked to undergo a research 60 minute research MRI, or to add 15-30 minutes of research scanning to their clinically indicated MRI. This study will help us learn more about imaging that may be particularly helpful for detecting and treating cerebrovascular diseases.
Eligibility Requirements

Moyamoya Imaging,
Neurologic and Cognitive Study

Overview
The MINC study aims to enroll children with moyamoya, or suspected moyamoya disease, prior to surgery. Participants will be asked to undergo a 45-60 minute research MRI. If the patient has a clinical MRI, an additional 15-30 minutes of research imaging can be added. In addition to an MRI pre-surgery, if surgery is indicated, participants will be asked to complete a survey and an ipad game to assess cognitive functioning. Researchers will collect clinical data about symptoms, treatment and recovery.
Eligibility Requirements

7T MRI MRA and Vessel-Wall Imaging for Cerebrovascular Disorders

Overview
A 7 Tesla MRI allows investigators to collect more detailed pictures than a 1.5T or 3T MRI. Investigators will be evaluating a radiographic biomarker in participants with unruptured brain aneurysms, moyamoya, and other cerebrovascular diseases before and after treatment interventions. Patients will undergo a clinically indicated 7T MRI located at Brigham and Women’s Hospital and consent to their imaging data being transferred to BCH for analysis. Research staff will collect clinical data through medical chart review and will correlate with clinical follow-up, findings from computational fluid dynamic modeling, and findings from histological analysis when tissue is available.
Eligibility Requirements
MINC
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Clinical Studies

A data collection study for cerebrovascular disease involves gathering and analyzing information about the incidence, prevalence, risk factors, treatment outcomes, and other relevant aspects of cerebrovascular disease. This type of study may involve collecting data from medical records, diagnostic tests, patient surveys, and other sources to better understand the impact of cerebrovascular disease on individuals and populations. The goal is to generate valuable insights that can inform healthcare practices, public health policies, and further research efforts related to cerebrovascular disease.

Fetal Embolization for Vein of Galen Malformation

Overview

The study is a clinical trial of transuterine ultrasound-guided embolization of vein of Galen malformation in second and third trimester fetuses who are at high risk of devleoping heart failure and brain injury after birth. Extensive imaging and clinical data collection and analysis is involved, both prenatally and postnatally.

Elegibility Requirements

Please contact the research team to find out if you/your child qualifies for the study.

Fetal Emobilization
Advanced Neurovascular Imaging and Research Clinical Studies
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Cerebrovascular International Registry

Overview
The Cerebrovascular International Registry is a collaboration with The Hospital for Sick Children in Toronto, CA as well as sites worldwide. We aim to collect data on different types of stroke, stroke risk factors and cerebrovascular disorders. Participants will consent to allow researchers access to their medical record to collect clinical information and clinical MRIs so that we may better understand these disorders and how to best to treat them.
Eligibility Requirements
Advanced Neurovascular Imaging and Research Clinical Studies
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Boston-London-Toronto Rare Cerebrovascular Disease Consortium

Overview
The Boston-London-Toronto Consortium aims to combine the experience of referral centers across different countries to provide consolidated perspective on rare disorders. The first initiative has centered on Cerebral Proliferative Angiopathy (CPA) which is reported in isolated case reports with the exception of one initial proposed cohort. The Boston-London-Toronto combined experience numbers up to nearly 50 cases and benefits from integrated multidisciplinary expertise (neurology, neurointervention, and neurosurgery).
Eligibility Requirements
BLT
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Biological Studies

A genetic study for cerebrovascular disease involves investigating the role of genetic variations in predisposing individuals to the disease. Researchers analyze the genetic makeup of individuals with cerebrovascular disease to identify specific genes or genetic mutations associated with an increased risk of developing the condition. This type of study can provide valuable insights into the underlying genetic factors contributing to cerebrovascular disease, potentially leading to the development of targeted therapies and personalized treatment approaches. Additionally, genetic studies can offer valuable information for understanding the hereditary components of cerebrovascular disease, which can be important for identifying individuals at higher risk and implementing preventive measures.

Advanced Neurovascular Imaging and Research Biological Studies

Cerebrovascular Disorders Sequencing Initiative

Overview
The Cerebrovascular Disorders Sequencing Initiative provides a type of genetic testing called Whole Exome Sequencing (WES) for patients with cerebrovascular disorders, who do not have a previously identified molecular diagnosis that fully explains their condition. The goal of the study is to identify underlying genetic causes of cerebrovascular disorders using genetic sequencing so that in the future we can develop better treatments for these conditions. Participation includes signing a consent form and providing a cheek swab sample which can be collected at Boston Children’s Hospital or at home. The study is free of charge and the genetic data is typically returned within 3-4 months.
Eligibility Requirements
Please contact the research team to find out if you/your child qualifies for the study.
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